Safety and Efficacy of Red Yeast Rice (monacolin-K)

Matthew Klimek, PharmD, Shan Wang, PharmD, and Adeleye Ogunkanmi, PharmD Abstract Red yeast rice is a Chinese fermented rice product (Monascus purpureus) that some have claimed improves blood circulation by decreasing cholesterol and triglyceride levels in humans. The supplement contains naturally occurring monacolin K, the active ingredient found in Merck’s prescription agent lovastatin (Mevacor). Lovastatin is associated with …

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Monacolins in Red Yeast Rice Extract

1.2. Monacolins in RED YEAST RICE EXTRACT (RYR) RED YEAST RICE EXTRACT (RYR) contains several types of secondary metabolites that have biological activity, including Monascus pigments, monacolins, gamma-aminobutyric acid, dimerumic acid, enzymes, polysaccharides, ergosterol, polyketides, unsaturated fatty acids, phytosterols, isoflavones, alkaloid, and trace elements [15,16,17]. Secondary metabolites in RED YEAST RICE EXTRACT (RYR) have been shown to have …

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